Alongside the online gallery, Brighton Dome will play host to
a public Big Heart exhibition
from Wednesday 4 to Friday 6 March.
The exhibition is free to enter and will be an opportunity to see first-hand artworks from a wide range of artists. All of the works can be viewed
"There is something for everyone" says June Frickleton, Big Heart curator and art expert.
"The auction includes a wide range of styles to appeal to all tastes and budgets, including photography, textile, mixed media, fine and contemporary art.
"We have pieces from local, national and celebrity artists, illustrators and photographers as well as 15 special artworks created by children at Chestnut Tree House."
Amongst the artworks is an original illustration from the David Walliams book, Awful Auntie.
The Illustration, Owl, has been signed by its creator Tony Ross and by Walliams himself and is accompanied by a signed copy of the book that the picture is from.
David Walliams said: "I was only too happy to get involved with Chestnut Tree House's inaugural Big Heart Auction,
"Last year I saw first-hand the amazing work the hospice does caring for children with life-shortening conditions and their families when
"I was privileged enough to visit the house and read to the children.
"I know that the funds raised from the auction will make a real difference to children and their families across Sussex."
A number of other artworks have been donated by local and national celebrities.
John Shuttleworth – who has painted Adam and Eve in the Garden Centre – says about his piece:
"This is the most memorable painting I've done since I drew a sedan chair in J3.
"What I mean is – I can't remember doing any other paintings since then.
"It, of course, depicts Adam and Eve in the Garden Centre – by which I mean, the centre of the Garden of Eden.
"I do hope you understand this complex modern work and appreciate it more than my wife, Mary, does.
"And if you are prepared to pay thousands of pounds to own it, then I will be overjoyed, not to mention, amazed."
Actress, comedienne and writer Carol Cleveland, best known as the '7th (Monty) Python' has contributed a piece entitled Imagination.
Carol said: "I paint for fun and this acrylic piece is my first attempt at modern art. I loved doing it!"